动物造模,2型糖尿病 z-bio 2021-07-02 313

　　Purpose: Observe the biological characteristics of db/db mice, and provide a basis for the experimental research and application of this strain of animals.

　　Method: Spontaneous type 2 diabetes BKS. Cg-Dock7m +/+ Leprdb/JNju and wild-type mice were used to measure fasting blood glucose levels at 8, 12, 16, 20, and 24 weeks of age. complete. , 12, 16, 20, 24 weeks of age, weight measurement, serum insulin, total cholesterol, triglyceride level measured at 24 weeks of age, organ mass and liver coefficient measurement, histopathological observation, I found us.

　　Result: The fasting blood glucose and body weight levels of db/db mice are always high. Serum insulin, total cholesterol, triglyceride levels and liver and kidney quality were significantly higher than wild-type mice. 24 is obvious. Pathological changes appeared in the pancreas and liver tissues of 1 week old db/db mice.

　　Conclusion: db/db mice have obvious characteristics of type 2 diabetes such as hyperglycemia, hyperlipidemia, and hyperinsulinemia, and are ideal animal models for experimental research on type 2 diabetes.