动物造模,肝炎病毒感染模型 z-bio 2021-07-03 298

　　Hepatitis B virus is the prototype of liver DNA virus. Hepatitis B caused by HBV infection is a public health problem that seriously threatens people's health. Existing anti-hepatitis B drugs such as nucleoside analogs and interferons are difficult to obtain clinically. Treatment and research of new anti-hepatitis B drugs? Appropriate animal models are essential for evaluating new combination treatment strategies. Groundhog Hepatitis Virus (WHV) was first discovered in the Philadelphia Zoo in 1978 when the zoo was suffering from liver cancer. The replication cycle is very similar to HBV, but is it classified as a hepatotropic DNA virus? The woodchuck model was used early for hepatitis B because the natural history of woodchuck infection with WHV is very similar to the history of human infection with HBV. vaccine? Evaluation of anti-hepatitis B virus drugs? In recent years, various woodchuck cytokines and their receptors? Immune cell surface markers have been cloned and identified. Does T cell response test include lymphocyte proliferation test? CD107a threshing experiment was gradually established. Have you greatly promoted the application of the woodchuck model in the pathogenesis of HBV and immunomodulatory therapy?