乙型病毒性肝炎,动物造模 z-bio 2021-07-03 1194

　　There are approximately 240 million patients with chronic hepatitis B in the world, of which 15-40% develop serious liver diseases, such as cirrhosis and hepatocellular carcinoma. As a result, more than 780,000 people die every year. Although HBV vaccines and antiviral drugs are being manufactured, hepatitis B is still an infectious disease and poses a serious threat to human health. HBV infection and replication cannot directly damage liver cells. The clinical symptoms are caused by the complex interaction between the host's immune response and the virus, leading to the development of liver cirrhosis and liver cancer. Due to the limitation of the HBV host, there is no ideal HBV animal model to study how HBV interacts with the host to cause chronic infection. At the same time, the mechanism of chronic infection leading to liver damage, cirrhosis and hepatocellular carcinoma is still unclear. This article introduces the existing HBV animal models based on the type of infection source, pathophysiological changes, and the occurrence and development of liver cancer. Researchers will use different models and use them in future HBV research for you to apply and compare.