动物造模,自发性肿瘤 z-bio 2021-07-07 883

　　Purpose: To observe the occurrence of spontaneous tumors in SD rats and provide background information for the development of carcinogenicity studies of new drugs. In the French carcinogenicity study, 120 4-week-old SPF SD rats (half each male) were observed in a normal control group. One week before the experiment, 104 weeks after routine administration, they were euthanized. feed. Rats that died and were put to death during the experiment were dissected and weighed every day for their heart, lung, liver, spleen, kidney, adrenal gland, thymus, brain, testis, and epididymis (or uterus). Spontaneous tumors of various organs.

　　Result: A total of 113 SD rats were observed (7 were lost during the experiment). Rats affected by tumors accounted for 66.4~75/113), of which benign tumors accounted for 48.7~55/113), which were malignant. Tumors accounted for 17.7~20/113). Tumors occurred in male rats from 49.1 to 28/57), of which 50.9 to 26/57) were benign tumors and 3.5 to 2/57) were malignant tumors. The benign tumors were mainly pituitary adenomas. It was 36.8°. Large adrenal medullary adenoma (7.0?, malignant tumors are mainly thyroid adenocarcinoma (18? and fibrosarcoma (1.8?. 83.9? 47/56) female rats have tumors, of which 51.8? 2956) are benign tumors, 32.1 18/56) are malignant tumors, and benign tumors are mainly pituitary adenomas (50.0?.) and breast fibroadenoma. (12.5? and breast adenoma (12.5) malignant tumors are mainly breast adenocarcinoma (25.0? and fibrosarcoma (3.6?.

　　Conclusion: The incidence of spontaneous tumors and benign tumors in SD rats over 2 years old is higher than malignant tumors, which is related to aging, tumors and individual differences.