【Animal Modeling】-Comparison of the four test results of SD rats with two different reagents

  Purpose: To obtain the results of four blood coagulation tests (PT, APTT, TT, FIB) in SD rats and human (PT, APTT, TT, FIB) experimental animals, and the results of blood cell aggregation tests of two different brands in Japan and Japan . Imported, compared with reagents. Observe whether there are differences between them.

  Method: Select SPF grade SD rat and human coagulation specimens, and use domestic and imported four different brands of coagulation reagents to perform PT, APTT, TT, FIB coagulation, and detect the indicators.

  Results: The detection results of the four coagulation indexes of rats by two different brands of coagulation reagents were different. The coagulation indexes PT, APTT, and FIB domestic reagents detection results of rats were higher than the detection results (Pu003c0.05); TT imported reagents coagulated mice The index test result is higher than the test result of domestic reagent (Pu003c0.05); on the other hand, the test result of TT imported reagent on mouse coagulation index is higher than the test result of domestic reagent (Pu003c0.05); there is a significant difference in human coagulation samples. No.

  Conclusion: The results of four coagulation tests (PT, APTT, TT, FIB) on SD rats using coagulation reagents from different manufacturers may be different. Each laboratory may have different results according to its own needs. The background data needs to be established.