动物造模 z-bio 2021-10-29 273

　　Objective: To study the effect of curcumin on the viability of rats in dry and hot desert environment.

　　Method: 40 SPF male SD rats aged 6-8 weeks were selected and randomly divided into a control group, a low-dose curcumin pretreatment group, a medium-dose curcumin pretreatment group, a high-dose curcumin pretreatment group, and a solvent group. I did it. The control group was fed normally, and the low-dose group, middle-dose group, high-dose group, and solvent group were given equal amounts of gastric administration for 7 consecutive days. Installed in the northwest special environment artificial laboratory, set the desert dry/high temperature environment climate mode (temperature 41℃, humidity 10? Ultraviolet 40W/m2). Observe the vital signs of rats in each group, monitor changes in core body temperature every 30 minutes, and record the time of death.

　　Result: Five groups of rats were placed in a dry desert environment for 0-30 minutes. The core body temperature of the three-dose curcumin group was not significantly different from that of the control group and the solvent group (P). → 0.05). Starting from 60 minutes, the core body temperature of the low-dose group, middle-dose group and high-dose group was lower at 7 points: 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes, 210 minutes, and 240 minutes. it is. There was a significant difference between the control group and the solvent group (P0.05). The average survival time of the five groups of rats in the control group, curcumin low, medium and high dose treatment group and solvent group were (222.95±28.23) minutes, (231.35±40.96) minutes, (255.00±30.39) minutes and (263.80 ± 56.71) respectively. ) Minutes, (223.00 ± 27.23) minutes. The survival time of rats in the medium and high dose curcumin pretreatment group was significantly longer than that of the low concentration pretreatment group, control group and solvent group (Pu003c0.05), and the effect of the high dose group was significant (Pu003c 0.01).

　　Conclusion: Curcumin pretreatment can improve the survival rate of rats in dry and hot desert environments, and curcumin plays an important role in improving the heat tolerance of rats in dry and hot desert environments. Curcumin may play a role, suggesting that curcumin may be the cause of heat radiation in the dry and hot environment of the desert. It has potential clinical application value in prevention and treatment.