动物造模,高脂血症小鼠 z-bio 2022-02-01 408

　　Objective: To investigate the effect of the combined action of estrogen and male hormones on the blood lipid level and coagulation function of hyperlipidemia mice.

　　Method: After the mice were castrated, a high-fat diet was used to establish a hyperlipidemia model. The mice were divided into 5 groups according to different hormones. After establishing the model, blood was drawn from the mice, separated from the serum to detect the blood lipid level of the mice, and part of the mice were separated from the plasma to detect the coagulation function.

　　Results: After a high-fat diet, the serum levels of total cholesterol, triglycerides, and low-density lipoprotein in mice were significantly higher than those of the control group, and prothrombin time and activated partial prothrombin time were significantly reduced (Pu003c0. 05) estrogen After combined treatment with male hormones, the serum total cholesterol, triglycerides, and low-density lipoprotein levels of mice were significantly lower than those of the control group, prothrombin time and activated partial prothrombin time were significantly reduced and prolonged (P\u003c0. 05), but there is no significant difference from the control group.

　　Conclusion: Combination therapy with estrogen and androgen can regulate blood lipids, significantly reduce low-density lipoprotein levels, and regulate blood coagulation. This is a new idea for hormonal treatment of coronary heart disease. The combined effect of estrogen and androgen reduces the risk of coronary heart disease.