动物造模,大鼠颅骨缺损后软组织再生 z-bio 2021-07-14 512

　　OBJECTIVE: To evaluate the ability of two new types of biodegradable polycitric acid biomaterials to induce soft tissue regeneration after skull defects in rats.

　　Methods: 46 male Sprague Dawley rats were randomly selected from 6 SD rats and transplanted into the thigh muscles. Materials were collected after 2 weeks. The remaining 40 skull defect models were randomly selected from 4 models. Grouping: control group, autologous bone transplantation Group and two new citrate material transplantation groups (10 animals in each group). Three months after treatment, samples were taken for histological staining and morphological analysis.

　　Results: 1.2 Two new polycitric acid biomaterials can induce regeneration of muscle and soft tissue; 2. Two new polycitric acid biomaterials can induce regeneration of blood vessels and fibrous tissues in rats with skull defects; 3.2 Two new biomaterials polycitric acid Biomaterials accelerate intramembrane regeneration by inducing soft tissue regeneration to form bone after skull defect.

　　Conclusion: The two kinds of biomaterials have excellent soft tissue regeneration inducing effects, effectively stimulating the regeneration of soft tissue at the skull defect, accelerating the development of intracranial bone formation, and ultimately promoting healing in the skull.