动物实验 z-bio 2021-07-15 548

　　Pre-clinical data published in the Journal of Clinical Research and The Globe and Mail indicate that pre-clinical data can lead to long-term cognitive dysfunction, even after the use of anesthesia or even after the drug is no longer effective.

　　Researchers injected a certain amount of anesthetic to the mice to calm them down instead of unconscious. The exposure to anesthetics was very short, but the cognitive impairment in the mice lasted for at least a week. "I don't know what this means for patients," said co-author Oser, but she pointed out that one week is "a long period of time for the mouse to live." She added that brain receptors are "very sensitive to anesthetics." "One of the hypotheses we are trying to prove is that when a drug fails, the function of these receptors will return to normal...but there are currently no clinical symptoms that meet the requirements."

　　Currently, it is well known that disease, inflammation, opioids, stress and lack of sleep can also cause postoperative cognitive dysfunction during postoperative recovery. Taking action on specific goals is one of the main causes of memory loss.

　　Scientists are looking for different ways to reduce the potential cognitive side effects caused by general anesthesia. Orser pointed out that dexmedetomidine acts on different types of receptors than the drugs commonly used in general anesthesia, and studies have found that the drug does not cause long-term memory loss.

　　Medetomidine is not very effective as an anesthetic, but in some cases a sedative is sufficient, or it can be used as an adjunct to general anesthesia. This "reduces the dose of anesthetic."