动物造模 z-bio 2021-07-16 799

　　Objective: To study the effects of benzene on liver and kidney function and blood nucleotide levels in Wistar rats.

　　Methods: Wistar rats were fed with different concentrations of benzene for 21 days, the contents of different components in the blood were detected with an automatic biochemical analyzer, and the click adenosine acid (cAMP) and cyclic phosphate blood bird were detected by enzyme-linked immunosorbent assay (ELISA) Glycoside (cGMP) and Heat Shock Protein 70 (HSP-70) levels.

　　Results: After administering different benzene doses of 0.19, 0.38, 0.76 g/(kg?bw) in Wistar rats for 21 days, the total bilirubin levels in the animal plasma were 134.40?173.63? Compared with the control group, an increase of 254.75? . Aspartate aminotransferase increased by 70.76?85.44?106.61? Creatinine increased by 24.54?67.46?84.50? Creatine kinase increased by 151.35?180.85?245.54?245.546ure group] 0.48?23.43? Alanine transferase level exceeded the detection value The upper limit is 1185.60? The cAMP level increased by 41.84?264.02?314.23? The cGMP level increased by 31.29?40.42.142? Compared with the control group, HSP-70 increased by 82.11?187.37?1484.21? ?64.45?

　　Conclusion: Benzene pollution can change the ratio of cAMP to cGMP in the blood, cause metabolic disorders, and cause liver and kidney damage or diseases.