动物造模,多囊卵巢综合征模型 z-bio 2021-07-16 597

　　Objective: To observe the effects of sex hormones, anti-Müllerian hormone (AMH), Bushen Fufang Ovulation Decoction on ovarian morphology in rats with polycystic ovary syndrome, and observe the mechanism of action of Bushen Fufang Ovulation Decoction (polycystic ovary syndrome, PCOS).

　　Method: Apply Bush and Ovulation Decoction to DHEA-induced PCOS rat model for ovarian morphology analysis and serum sex hormone and AMH detection.

　　Results: Compared with the normal group, the ovaries of the model group showed diffuse cysts with severe expansion and cysts of varying sizes were seen. The granule cells are compressed into a flat or cube shape. Various developmental cysts were found in the corpus luteum. There are several stages of the corpus luteum. Bushen Promoting Ovulation Decoction can significantly increase the number of mature follicles, corpus luteum, sex hormones, and AMH levels in PCOS model rats, which are significantly different from the model group (Pu003c0.05).

　　Conclusion: Bushen and Ovulation Decoction increases serum sex hormone levels in PCOS model rats, reduces serum AMH, restores ovarian ovulation function, and achieves a therapeutic effect on polycystic ovary syndrome.