动物造模 z-bio 2021-07-20 324

　　Objective: To compare the bone-improving effects of calcium chelated collagen polypeptide (CPCC) and estrogen, and lay the foundation for the development of safe osteoporosis (OP) prevention and treatment drugs.

　　Method: Excise both ovaries in rats, ovariectomized group (OVX), sham operation group (sham), 17β-estradiol (OVX+E2) injection group and CPCC gavage group (OVX+CPCC), 9 groups of bones. After 1 week, the indexes of each group and blood biochemical indexes were compared.

　　Result: The femoral mineral density of the OVX group was significantly lower than that of the sham group (P0.05). But in terms of inhibiting weight gain, the weight of the E2 group in the 8th and 9th weeks was significantly lower than that of the sham group (Pu003c0.01). In preventing the loss of bone minerals and bone organic matter. The Mg and Ca levels of E2 group were significantly lower than CPCC. In the high-dose group, the Cu level did not change compared with the sham operation group, but was significantly higher than the CPCC (medium and low dose) sham operation group. The levels of Mn, Zn, and hydroxyproline in the E2 group were significantly lower than those in the sham operation group, but CPCC could be maintained at the level of the sham operation group. There was no significant difference between E2 group and OVX group in inhibiting the increase of blood BGP and StrACP levels, CPCC group was significantly lower than OVX group. When the decrease in blood calcium concentration was inhibited, there was no significant difference between the E2 group and the OVX group, but the CPCC group was significantly higher than the OVX group.

　　Conclusion: Calcium chelated collagen peptide is more effective than estrogen in improving the bone quality of ovariectomized rats.