动物造模 z-bio 2021-07-21 369

　　Objective: To study whether pine pollen has inhibitory and synergistic effects on paclitaxel combined with platinum chemotherapy.

　　Method: transplantation of human lung cancer H460 cell line into 48 nude mice, model group 3 doses, pine pollen 600, 300, 150 mg/kg + TP regimen chemotherapy group, 3 times according to the principle of TP alone. The tumor volume balance chemotherapy group has three single-dose groups of 600, 300, and 150 mg/kg pine pollen, with 6 rats in each group. After administration of each group, the weight of nude mice, food intake, tumor inhibition rate, hematology, liver and kidney function were used as evaluation indicators to comprehensively evaluate the effect of pine pollen on TP. Have. Chemical treatment.

　　Result: When TP regimen chemotherapy of model animals was given pine pollen (150, 300, 600mg/kg) at the same time, the tumor inhibition rate of TP chemotherapy regimen alone was significantly increased, and chemotherapy drugs reduced and inhibited chemotherapy-induced leukopenia and liver and kidney damage.

　　Conclusion: Simultaneous administration of pine pollen and TP regimen chemotherapy has an important effect of increasing efficiency and reducing toxicity.