动物造模 z-bio 2021-07-21 438

　　Objective: To evaluate the effect of continuous high frequency sine and square wave frequency flash on the emmetropia and eye development of guinea pigs.

　　Method: 30 2-week-old guinea pigs were divided into 3 groups (n=10): 20Hz square wave, 20Hz sine stroboscopic effect group, and non-flicker control group (n=10), with uniform light intensity. 500 lx, measure the optical power of the guinea pig’s eye every two weeks, and measure the axis length and radius of curvature. Three groups of guinea pigs were examined by electrophysiological flash electroretinogram (F-ERG) at the 8th week, and histological changes were evaluated pathologically after the eyes were removed.

　　Results: The eyeball refractive power of the three groups of guinea pigs was positively correlated with the length of the eye axis. In the 8th week, compared with the control group, there were 20Hz sine strobe group and 20Hz square wave power (-0.75±0.79)D and (-1.50±)0.91)D. Myopia changes (P0.05), the F-ERG delay of 20Hz sine wave and 20Hz square wave stroboscopic group was extended by 3.8 seconds and 7.9 seconds. There was no significant difference in histology between the three pathological groups.

　　Conclusion: Continuous exposure to high-frequency square waves and sine stroboscopic flicker has certain effects on emmetropia.