动物造模 z-bio 2021-07-21 743

　　Objective: To study the relationship between changes in pulmonary artery pressure and changes in right ventricular function.

　　Methods: Four MCT-induced pulmonary arterial hypertension (PAH) model groups (12 in each group) were used to measure pulmonary artery pressure for 1, 2, 3, and 4 weeks using a right heart catheter. MRI right heart function dynamics was used to detect and observe pulmonary artery pressure and MRI parameters The change. Compare the differences of related parameters between the control group and the PAH model group. The SPSS17.0 statistical software was used to evaluate the correlation among right ventricular ejection fraction, right ventricular end diastolic volume, right ventricular end systolic volume, and average pulmonary artery pressure. Pearson correlation analysis was used. The comparison between groups was performed by completely random t test, and P\u003c0.05 indicated significant difference.

　　Results: The right ventricular ejection fraction, right ventricular end-diastolic volume, and mean pulmonary artery pressure (rRVEF =-) 0.823 of the 48 model rats have a good correlation between 1-4 weeks after monochromatic Tallinn injection. RVEDV = 0.732, rRVESV = 0.803). Two weeks before monocrotalin injection, the mean pulmonary artery pressure, right ventricular ejection fraction, right ventricular end-diastolic and end-systolic volume of the monopolytalin group were not significantly different from those of the control group (P\u003c0.05). After 3-4 weeks, the above parameters were significantly different from the control group (Pu003c0.05).

　　Conclusion: As the pulmonary artery pressure in rats increases, the right ventricular ejection fraction gradually decreases, and the right ventricular end-diastolic and end-systolic volumes gradually increase. When monitoring the rat model of chronic pulmonary hypertension, MRI can accurately and quickly measure the changes of various parameters. The right ventricular end-diastolic and end-systolic volume, ejection fraction and other parameters are sensitive parameters that cause pulmonary hypertension.