动物造模 z-bio 2021-10-12 720

　　Objective: To evaluate the effect of transverse bone wound healing agent on the blood physiological indexes and organ coefficients of Tupai castration osteoporotic fracture model.

　　Method: 30 female tree shrews were divided into control group, model group and treatment group. The tree shrews in the treatment group and the model group had their ovaries removed for 6 months and resulted in tibia fractures 6 months after osteoporosis. From the next day after the fracture, the treatment group took the transverse bone wound healing agent once every two days. The model group and the control group were given the same amount of normal saline. After 3 months of oral administration, the blood physiological indexes and organ coefficients of each group of tree shrews were tested.

　　Results: Among the 16 blood physiological indicators, the white blood cell count, lymphocyte count and percentage of the model group were significantly lower than those of the control group (Pu003c0.01), and the percentage and absolute values were monocytes. The proportion has also decreased (Pu003c0.05). Compared with the model group, the percentage and absolute value of monocytes in the treatment group increased significantly (Pu003c0.01), and the absolute value and absolute value of lymphocytes and the number of white blood cells increased significantly (Pu003c0.01) .01).u003c0. 05), the spleen coefficient of the treatment group was significantly higher than that of the model group (Pu003c0.05).

　　Conclusion: Henggu bone wound healing agent improves the immunity of osteoporotic fracture tree shrews.