动物造模 z-bio 2021-07-22 539

　　Objective: To observe the changes of dopamine (DA) content in the lateral geniculate body in guinea pig stroboscopic myopia and deprivation myopia models, and to conduct a comparative analysis to preliminarily explore the central etiology of various myopia models.

　　Method: 24 normal 2-week-old myopia pigs were randomly divided into three groups (n=8): strobe light (FLM) group, foam deprivation (FDM) group, control group and each group were cultivated for 8 weeks. Each group was measured before and after modeling. The refractive power and axial length of the right eye of a group of myopic pigs. After 8 weeks of experiment, did you use HPLC-ECD to quantify the DA of the left geniculate nucleus?

　　Results: There was no significant difference in refractive power and axial length of each group before modeling (P\u003c0.05). The change in refractive power of the right eye in the FLM and FDM groups compared with the control group at 8 weeks of modeling. (P control group→FDM group; control group is (37.04)±1.18) pg/μL; FDM group is (24.27±3.46) pg/μL, which is significantly different from the control group (P=0.021). FLM control group, this group is (45.58±1.98) pg/μL. Is the difference significant (P = 0.01)?

　　Conclusion: The DA content in the lateral geniculate nucleus of the myopia model caused by stroboscopic flashes increases, but the DA increases. The content of the deformed myopia model is reduced, indicating that DA is outside of the two experimental myopias. Is the expression of the geniculate body inconsistent, and the mechanisms of the two myopia models may be different?