动物造模,子痫前期大鼠小鼠模型 z-bio 2021-07-27 510

　　Pre-eclampsia (pre-eclampsia, PE) is a unique pregnancy disease, and it is one of the main causes of morbidity and death in pregnant women and perinatal infants. The cause is unknown, and abortion is now considered an effective treatment. With the progress of society, the demand for safety during pregnancy has gradually increased. Establishing an ideal PE animal model will better prevent or delay disease progression, reduce maternal weight, reduce fetal mortality, and improve pregnancy safety. Foundation and platform.

　　Big mice and mice are widely used in clinical animal research of major diseases due to their economy, accessibility, high survival rate, short pregnancy cycle and other advantages. Refer to domestic and foreign literature to summarize the PE models of large models and mouse models from the aspects of reduced uterine blood flow, excessive activation of inflammatory immunity, vascular endothelial cell damage, blood hypercoagulability, and gene recombination.