动物造模 z-bio 2021-07-28 627

　　Objective: To establish a latent infection model of SIVmac239 in rhesus monkeys, to study the expression characteristics of CD32 in resting, activated and/or memory CD4+ T cell subsets, and to analyze its potential as a marker of the AIDS latent pool.

　　Method: SIVmac239 chronically infected rhesus monkeys combined with antiretroviral therapy to establish SIVmac239 latent infection rhesus monkey model. This model is used to detect changes in plasma viral load, CD4+ T cell count, CD4/CD8 cell ratio, and CD32 expression of different CD4+ T cell subsets of samples at different stages.

　　"Compared with the results before infection, CD32 expression increased in activated naive T cells after SIV infection, and expression increased in HLA-DR+CD4+ T cells, but CD32 was dormant CD4+. There was no significant difference in the expression of resting memory T cell subsets.

　　Conclusion: This study provides data support for the view that CD32 is not a marker of the AIDS latent library, and provides information for subsequent AIDS treatment research.