动物造模,成年生长激素缺乏动物模型 z-bio 2021-07-29 316

　　Objective: To explore several methods for establishing adult growth hormone deficiency animal models, and to provide an excellent model for experimental research and treatment of abnormal bone metabolism caused by growth hormone deficiency.

　　Method: Reference literature to identify and evaluate how to establish an animal model of adult growth hormone deficiency.

　　Result: Adult growth hormone deficiency animal models can be divided into three types: natural growth hormone deficiency animal models, pituitary resection animal models, and gene knockout models.

　　Conclusion: The animal model of hypophysectomy is cheap and convenient to use, but there are many influencing factors. Not suitable for studying the relationship between growth hormone and bone metabolism. Although the animal models of spontaneous growth hormone deficiency and gene knockout animal models are expensive, some lack of growth hormone is suitable for studying the effect of growth hormone deficiency on bone metabolism.