动物模型 z-bio 2021-07-29 461

　　According to a study by Michigan State University, severe pulmonary hypertension, a rare disease found in dogs, has been classified as a human lung disease.

　　Kurt Williams is the lead author of this research report and a respiratory pathologist in the Department of Veterinary Medicine at Michigan State University. "Our research is the first to find obstructive diseases of the lung or peripheral blood vessels in dogs."

　　This research was published in the Journal of Veterinary Pathology.

　　Pulmonary hypertension, or the value of pulmonary hypertension, has a very low proportion of cases reported in the United States, which can infect 15-50 people per 1 million people per year. Among patients with pulmonary hypertension without other diseases, only about 10 patients have been diagnosed with peripheral vascular obstructive disease. Unfortunately, there are few effective treatment options for peripheral vascular obstructive diseases, and lung transplantation is often the most effective option.

　　Williams said: "Peripheral vascular obstructive disease may be more common in dogs than in humans, but this has not yet been determined and requires further investigation."

　　Pulmonary hypertension is abnormally formed in the lungs due to the presence of various blood vessels. This makes it more difficult for the heart to expel blood from the lungs and supply oxygen to other parts of the body. In the case of peripheral vascular obstructive disease, obstruction of the pulmonary venules can cause an increase in pressure in these blood vessels, which can eventually lead to heart failure.

　　Williams said: "The same pathological process occurs in dogs." "The symptoms of these dogs are similar to humans, but these subtle changes in their health are not immediately apparent. These diseases will die immediately when the dog is found by the veterinarian. ."

　　Symptoms include cough, dyspnea, dyspnea, loss of appetite, and chronic discomfort. The fatal progress of this human disease can last for two years.

　　Williams said: "Peripheral vascular obstructive disease is not only very rare, but also a poorly understood disease because it is not known that other animals also suffer from this disease." "Our discovery is that we may change some things. "

　　Williams said. This discovery is very important to the human medical community, because canine diseases can be used as a model for human peripheral vascular obstructive diseases.

　　He said: "Cases like this usually help remind us of the importance of veterinarians to medicine." "Colleagues in human medicine say that every patient has many diseases, and I. We are becoming more and more aware of how we learn of."