动物造模,糖尿病,动物模型 z-bio 2021-08-02 277

　　Diabetes mellitus is a metabolic disorder syndrome caused by a variety of reasons, usually characterized by chronic hyperglycemia. The etiology and pathogenesis of this disease are not yet fully understood, and there is a lack of targeted and effective treatment methods. Animal models of diabetes are the key to studying the causes and new treatments of diabetes. By observing the emergence of animal models during the modeling process and a series of reactions after the drugs act on the corresponding animal models, the etiology is as follows: directly or indirectly understood mechanisms and new drugs. Therefore, choosing a suitable diabetes model is a prerequisite for research. Initially, the World Health Organization (WTO) Diabetes Expert Committee divided diabetes into primary and secondary categories. In recent years, people’s awareness of diabetes has gradually increased. With in-depth research on its genetic susceptibility genes and immunology, the American Diabetes Association (ADA) Expert Committee has revised the classification of diabetes, and the new classification is membership diabetes. .. (T1DM), type 2 diabetes (T2DM), other special types of diabetes and gestational diabetes. Commonly used models for diabetes drug screening and treatment mechanism research include animal models, cell models, and molecular-level models. Animal models, also known as in vivo experimental models, are used to screen early and final drug validation for diabetes treatment. Cell models, also called in vitro experimental models, are used in the early stages of mechanism exploration and animal-level experiments. Animal genetic modification, or molecular level model, is also called genetic experimental model. Some genes are modified by gene editing technology such as ZFN/TALEN/CRISPR to study the influence of genes. Laboratory animals have a clear genetic background or a clear source of information, which is one of the basic conditions to support the development of modern science and technology (the other three elements are equipment and devices, information materials, and chemical reagents). They have been studied because of their many advantages Favorites and applications: (1) and human body structure, function, metabolism and disease characteristics; (2) Compared with human chronic diseases, the onset process is shorter and saves time; (3) "Replicated" diseases are easier to control , Eliminating the influencing factors that cannot be eliminated under natural conditions. (4) High copy rate, good reproducibility, etc.