动物造模,阿尔茨海默病 z-bio 2021-08-02 432

　　Alzheimer's disease is one of the dementias that damage human nerves caused by β-amyloid protein, and there is currently no cure. Prion protein is the receptor of β-amyloid protein, and is one of the important proteins in the pathogenesis of Alzheimer's disease. It has two functions of transmitting neurotoxicity and protecting nerve cells. The polymorphism of the human prion protein coding gene (PNRP) affects the incubation period and clinical manifestations of Alzheimer's disease, and the discovery of PRNP mutant mice enhances and complements the increased application value of animal models in the research of prion protein diseases. This overcomes the shortcomings of the existing animal models of Alzheimer's disease to a certain extent. This article reviews the role of prion proteins in the pathology of Alzheimer’s disease and the impact of PRNP mutations on Alzheimer’s disease. It summarizes the discovery of PRNP mutant mice and its application and value in the study of protein precipitation-like lesions. . Provide a theoretical reference for the study of Alzheimer's disease animal models.