动物造模,抑郁症小鼠 z-bio 2021-08-05 412

　　Objective: To investigate the effects of Vipromid capsules combined with fluoxetine hydrochloride capsules on depression in mice.

　　Method: Use chronic stress and orphans to establish a mouse depression model. They were randomly divided into 5 groups: blank control group, model group, virprozine hydrochloride group, fluoxetine hydrochloride group, fluoxetine hydrochloride group (combined drug group), with 10 rats in each group, and gavage for 30 days. For comparative analysis, observe the weight change, glucose water preference, forced swimming immobility time and tail suspension immobility time of each group of mice, and comprehensively evaluate the effect of combination medication on depressed mice.

　　Result: After the completion of the modeling (day 0), compared with the blank control group, the total sugar water consumption, sugar water preference and body weight of each depression model group were significantly reduced (P). u003c0.01). The animals in the experimental group gained weight after gavage. On the 30th day, the weight gain of the combination group was significantly different than that of the model group (Pu003c0.05). On day 39, there was a significant difference in weight gain in the dipropylamine group (Pu003c0.05). On day 46, there was a significant difference in weight gain between the combination group and the fluoxetine hydrochloride group (Pu003c0.05). On the 50th day, the total sugar water consumption and sugar water preference rate of each treatment group increased to varying degrees. Compared with the model, the total sugar water consumption and sugar water preference rate of the dipropylamine group were significantly different. Group. Compared with the model group, the total sugar and water consumption of the combination group also had a significant difference (Pu003c0.05), and the sugar and water preference rate of the combination group also had a huge difference (Pu003c0.05). u003c0.05). Pu003c0.01). The forced swimming immobility time and tail suspension time of the biprodin group and the combined drug group were significantly reduced, and the swimming and tail suspension time of the biprodin group were significantly different from the model group (Pu003c0.05). .. There is a significant difference in the immobility time of the tail suspension in the combination group (Pu003c0.01). Compared with the fluoxetine hydrochloride group, the immobility time of the tail suspension in the combination group was significantly different (Pu003c0.05).

　　Conclusion: Experiments show that virpromid has an antidepressant effect, and the combination with fluoxetine hydrochloride has an excellent effect. This study provides experimental evidence and references for clinical medications for clinical depression.