动物造模 z-bio 2021-08-05 404

　　OBJECTIVE: To study the toxicity of oral psoralen extracts to rats and provide evidence for the safety of its clinical application.

　　Methods: 112 SD rats were divided into 8 groups according to gender and body weight: control group, solarin drug group, solaren lower penetrant high-dose group and low-dose group, upper penetrant high-dose group and rutin low In the dose group, the low-dose group has high sunlight penetration residue [the dose of crude drug group (crude drug) is 3 g/kg body weight, the high dose and low dose (crude drug) of other administration groups are 6 and 3 g/kg body weight, respectively], 14 groups of animals. The drug was administered continuously for 4 weeks. After the administration period, fasting, and water for 12 hours, blood was drawn to test the relevant blood biochemical indicators, the organs were dissected, the organs were weighed, the organ coefficients were calculated, and the liver tissue MDA was measured. , And histopathological examination.

　　Results: Compared with the control group, the liver organ coefficient, ALP, and MDA in the solar element drug group were significantly increased, and the thoracic organ coefficient and T-AOC were significantly reduced; the lower liver organ coefficient infiltration administration group, T-AOC, ALT Significantly increased, the liver organ coefficient and MDA of the high-dose Solaren osmotic drug group increased significantly, and the T-AOC value of female rats decreased significantly. There was no significant liver and kidney toxicity in the low-dose drug residue group; there was no significant difference in the psoralen exudate group.

　　Conclusion: Although the safety of the upper psoralen exudate is better than the lower psoralen exudate, the measurement results of the active ingredients show that the lower psoralen exudate is more suitable for human medication.