动物造模,胸主动脉瘤/夹层模型 z-bio 2021-08-12 1020

　　Objective: To explore a simple and rapid method to evaluate whether the mouse thoracic aortic aneurysm/anatomical animal model has been successfully established.

　　Method: 24 male C57BL/6 mice aged 3 weeks were randomly divided into model group and control group. The mice in the model group were fed a normal diet and drinking water dissolved in β-aminopropionitrile (BAPN) for 4 weeks, and the mice in the control group were fed a normal diet and drinking water. The body weight of the mice was dynamically monitored. At the 4th week of modeling, the mouse thoracic aorta and left common carotid artery were detected by the Vevo2100 small animal ultrasound system, and the mouse thoracic aorta was observed. Micro CT.

　　Result: Compared with the control group, the weight of the model mice was significantly reduced in the 4th week. The small animal ultrasound and micro-CT detection model showed the thoracic aorta of the model. The ultrasound model group can detect changes in pulse wave velocity and significantly improve the degree of arteriosclerosis.

　　Conclusion: Small animal ultrasound is easy, fast and safe to evaluate whether the mouse thoracic aortic aneurysm/dissection model is successfully established, dynamically observe the changes in the size of the thoracic aortic aneurysm/dissection, and dynamically observe the degree of arteriosclerosis.