动物造模,心搏骤停兔模型 z-bio 2021-09-17 287

　　Objective: How to compare the characteristics of the physiological indicators of cardiopulmonary resuscitation (CPR) in two rabbit models of potassium chloride-induced cardiac arrest and esophageal electrical chest wall tremor?

　　Method: New Zelan rabbits were divided into potassium chloride induced tremor group (10? potassium 0.3 mL/kg pulsed intravenous injection to induce cardiac arrest) and electric tremor were classified as combat group (transesophageal chest wall using 35 mA) by random number table. AC current induces cardiac arrest). 5 CPR after cardiac arrest? Do you want to compare the time to induce cardiac arrest? What is the time for cardiopulmonary resuscitation? Recovery of Spontaneous Circulation (ROSC)? Arterial blood gas and blood lactic acid (Lac) levels 1 hour after spontaneous circulation is restored, and survival rate 72 hours after resuscitation?

　　Result: Did all 20 animals successfully induce cardiac arrest? Compared with the electrical fibrillation group, the cardiac arrest time [(27.40±6.48) s compared with (9.90±2.47) s] and the cardiopulmonary resuscitation time [(132.00±. 18.55) in the potassium chloride-induced tremor group were (61.61±26.51)) s] is significantly shorter than s (Pu003c0.01)? Both the potassium chloride induced tremor group and the electric tremor group had 9 animals recovering spontaneous circulation. The animal survived within 72 hours. 5 animals. Compared with the electric shock group, the potassium chloride tremor group had arterial blood gas pH [(7.38±0.06) vs. (7.29±0.11)] and HCO3 concentration [(18.32) .(21.86±3.65) 1 hour after spontaneous circulation was restored. mmol/L] significantly increased (Pu003c0.05) compared with ±2.61)mmol/L and compared with (1.77±0.77)mmol, the Lac level [(5.39±3.40)) was/L mmol/l) was significantly reduced ( Pu003c0.01) and the difference in oxygen partial pressure (PO2), carbon dioxide partial pressure (PCO2) and K+ concentration is not statistically significant? Conclusion Compared with the esophageal chest wall AC electrical stimulation and potassium chloride pulse infusion, it can induce cardiac arrest in rabbits more conveniently, the body environment is more stable after resuscitation, and the survival rate is higher.