动物造模,免疫系统人源化小鼠模型 z-bio 2021-08-20 306

　　Humanized mice are used to study the development and application of human immune cells, human autoimmune diseases, viral infections, transplantation biology and tumor biology. By transplanting mature human immune cells, fetal human thymus, bone marrow, liver tissue, etc., a mouse model with human immunity is constructed. An animal model with a humanized immune system will significantly promote our understanding of human immunobiology and immune-related diseases such as autoimmune diseases, viral infections, tumors and transplant rejection. These animal models are important research tools for studying human lymphocyte biology and immune response. There are already methods for exploring humanized mouse human cells. Humanized mouse A mouse composed of human cells, tissues, organs and even human genes, including models transplanted with human lung, kidney, pancreas, stomach, liver, ovary, endometrium, nerve and skin tissue. Severe combined immunodeficiency (SCID) or recombination activating gene (Rag) mice lack T and B cells, and were initially used as recipients to rebuild human immunity. Recently, more and more genetically modified SCID or Rag mouse models have been used, including SCID, NOD/SCID, Rag null and NOD/LtSz-Rag1 null Pfp null, etc. These mice are innately immunodeficient. As a living model for studying human diseases, the humanized mouse model has great advantages and broad application prospects in elucidating pathogenesis and drug screening. This review mainly introduces the current status and research progress of humanized mouse models of the immune system.