动物造模,功能性消化不良脾虚证大鼠模型 z-bio 2022-01-15 751

　　Objective: To discuss the establishment and comparison of animal models of functional dyspepsia with spleen deficiency syndrome.

　　Methods: Rat models of functional dyspepsia with spleen-deficiency syndrome were established by iodoacetyl and compound platform standing or compound swimming methods respectively. Serum motilin, cholecystokinin, lactic acid, and lactic acid were detected by observing the general state of the animals, changes in body weight and food intake. The content of gastrin and urinary D-xylose excretion rate were used to evaluate the effect of modeling.

　　Results: Rats in the iodoacetamide single-factor group had slower weight gain and reduced food intake; rats in the compound-factor group showed symptoms of spleen deficiency such as weight loss, shrunken hair, and diarrhea, and the urinary D-xylose excretion rate, serum motilin, The content of gastrin was significantly reduced, while the content of serum cholecystokinin and lactic acid was significantly increased.

　　Conclusion: All three modeling methods can cause functional dyspepsia with spleen-deficiency symptoms, but the spleen-deficiency symptoms are more obvious in the compound-factor treatment group, and the iodoacetamide composite small platform standing method has the best effect.