动物造模,关节炎小鼠模型 z-bio 2021-08-23 216

　　Objective: To establish and analyze the arthritis model of conditional infection with Staphylococcus aureus, and to provide an animal model for the study of arthritis mechanism and drug development.

　　Method: The mice were first treated with cyclophosphamide immunosuppressive treatment, and then the tail vein was inoculated with Staphylococcus aureus. The model was evaluated by the observation of joint appearance characteristics, arthritis index analysis and pathological observation score.

　　Results: From the first day after vaccination, the joints of the mice were slightly swollen, and the joint tissue lesions developed from a small amount of synovial hyperplasia and disordered arrangement to thickened synovium, extending into the joint cavity, and increased infiltration of neutrophils, etc. Pathological changes.

　　Conclusion: The successful establishment of a conditional infection SA model can simulate the clinical symptoms and course of human arthritis in a relatively short period of time, and reflect the etiology of human arthritis in terms of infection and immune mechanisms.