动物造模,动脉粥样硬化 z-bio 2021-09-06 307

　　Objective To observe the effect of Naoshuantong Capsules on blood lipid levels in atherosclerotic mice, and to explore the mechanism of Naoshuantong Capsules in the treatment of stroke.

　　Method 6-week-old male ApoE-/- mice were established with high-fat diet to establish atherosclerosis model. After successful modeling, they were randomly divided into model group, Naoshuantong Capsule low-dose group, and Naoshuantong Capsule high-dose group. The low-dose group was given Naoshuantong capsules 0.5g/kg body weight, the high-dose group was given Naoshuantong capsules 1.0g/kg body weight, and the control group was given the same amount of distilled water. After 12 weeks of continuous administration, blood was taken from the abdominal aorta and the serum was separated. Enzyme-coupled colorimetric method for determination of serum total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein cholesterol lipoprotein-cholesterol, HDL-C) levels.

　　Results Compared with the model group, the Naoshuantong Capsule low-dose group and high-dose group significantly reduced the content of TC, TG and LDL-C in the serum, but had no effect on the content of HDL-C.

　　Conclusion Naoshuantong Capsules can regulate blood lipid levels, and its mechanism of treatment of stroke is probably related to this approach.