动物造模,抑郁症小鼠 z-bio 2021-09-06 299

　　Objective To investigate the effect of Vipromide Capsules combined with Fluoxetine Hydrochloride Capsules on depression in mice.

　　Method The method of chronic stress and orphaning was used to establish a mouse depression model. Randomly divided into 5 groups: blank control group, model group, viprozine hydrochloride group, fluoxetine hydrochloride group, and viprozine combined with fluoxetine hydrochloride group (combined medication group), 10 rats in each group, and continuous intragastric administration for 30 days. The body weight changes, sugar water preference rate, forced swimming immobility time and tail suspension immobility time of each group of mice were observed for comparative analysis, and the effect of combined medication on depression mice was comprehensively evaluated.

　　Results When the modeling was completed (day 0 of administration), compared with the blank control, the total consumption of sugar water, sugar water preference rate and body weight of each depression model group were significantly reduced (P<0.01). After intragastric administration, the body masses of the animals in the experimental groups increased. On the 30th day, compared with the model group, the body mass growth of the combined drug group had a significant difference (P<0.05). On the 39th day, the vinpropylamine group There was a significant difference in body mass gain (P<0.05). On the 46th day, compared with the fluoxetine hydrochloride group, the combined administration group showed a significant difference in body mass gain (P<0.05). On the 50th day, the total sugar water consumption and sugar water preference rate of each treatment group increased to different degrees. Compared with the model group, there were significant differences in the total sugar water consumption and sugar water preference rate of the vinpropylamine group (P<0.05) , Compared with the model group, the total consumption of sugar and water in the combination group has a significant difference (P<0.05), and the preference rate of sugar and water in the combination group has a very significant difference (P<0.01). The time of forced swimming immobility and tail suspension time in the viprozine group and the combination medication group were significantly reduced. Compared with the model group, the swimming and tail suspension time of the viprozine group had significant differences (P<0.05). The combination medication group The immobility time of tail suspension was significantly different (P<0.01). Compared with the fluoxetine hydrochloride group, the immobility time of tail suspension in the combined medication group was significantly different (P<0.05).

　　Conclusion Experiments have shown that vilpromide has an antidepressant effect, and the combined effect of fluoxetine hydrochloride is better. This study will provide experimental evidence and references for clinical medications for clinical depression.