动物造模 z-bio 2021-09-15 495

　　The "heavy taste" diet has become a daily choice for most people, but a study in mice published by American scientists on the 14th in the British journal "Nature Neuroscience" found that a high-salt diet can affect the health of the brain-which leads to intestinal health. There are changes in the immune system, which in turn triggers cognitive deficits, and changes in lifestyle may change this result.

　　It is known that a high-salt diet can cause human blood pressure to rise and increase the risk of cardiovascular disease. At the cellular level, excessive salt intake can lead to abnormal functions of endothelial cells (covering the internal and external surfaces of blood vessels, regulating blood vessel tension), but the long-term effects of this abnormal function on different organs have been unclear.

　　The research team at Weill Cornell College of Medicine in the United States allowed mice to eat a high-salt diet this time-the proportion of high-salt levels in local human diets. After a few weeks, the mouse endothelial cells showed abnormal function, reduced cerebral blood flow, and showed cognitive impairment in multiple behavioral tests, but there was no change in blood pressure. The high-salt diet also increased the number of TH17 white blood cells in the intestines of mice and improved the level of a pro-inflammatory molecule (IL-17) released by these cells. The researchers found that it is the increase in IL-17 in the blood stream that causes the high-salt diet to have a negative impact on the function and behavior of the cerebrovascular.

　　Although these are based on mouse experiments, it also shows that IL-17 can affect human brain vascular endothelial cells in a similar way, which means that high-salt diet may have a negative impact on human brain health. It is worth noting that mice returning to a normal diet or through drug intervention can reverse the results of a high-salt diet, that is, changing lifestyles or developing new prescription drugs, which are expected to prevent or assist in reversing related results.