动物造模 z-bio 2021-09-15 261

　　Objective: To study the effect of resveratrol on the formation of blood hypercoagulability in rats and its relationship with the expression of NF-κB.

　　Methods: SD rats were divided into blank group, model group, high-dose resveratrol group (60 mg/kg), low-dose resveratrol group (30 mg/kg) and aspirin group (10 mg/kg), continuous After intragastric administration for 7 days, a hypercoagulable rat model was established by adrenaline combined with ice bath method and thrombin method, and blood samples were collected to measure prothrombin time (PT) and activated partial thromboplastin time (activated partial thromboplastin). time, APTT) and whole blood viscosity; vascular endothelial cells were collected, and the expression of NF-κB was measured by Western blotting.

　　Results: Compared with the model group, the PT and APTT of the blank group, high-dose resveratrol group and aspirin group were significantly prolonged (P<0.05), and the blood viscosity was significantly reduced (P<0.05); the high-dose resveratrol group NF of vascular endothelial cells The expression of -κB was significantly lower than that of the model group (P<0.05).

　　Conclusion: High-dose resveratrol (60 mg/kg) can inhibit the formation of blood hypercoagulability in rats, and this effect may be related to the reduction of NF-κB expression.