动物造模 z-bio 2021-09-17 431

　　Objective: To study whether pine pollen has attenuating and synergistic effects on paclitaxel combined with platinum-based planned chemotherapy.

　　Method: Take 48 xenograft nude mice prepared from human lung cancer H460 cell line and divide them into model group, three doses of pine pollen 600, 300, and 150 mg/kg + TP plan chemotherapy group, and TP plan alone according to the tumor volume balance criterion. The chemotherapy group and three single-dose groups of 600, 300, and 150 mg/kg pine pollen alone, each with 6 animals. After each group was given the corresponding drugs, the weight, food intake, tumor inhibition rate, hematology and liver and kidney function of nude mice were used as evaluation indicators to comprehensively evaluate whether pine pollen had the effect of enhancing and reducing the toxicity of the TP chemotherapy program.

　　Results: The model animals were given TP plan chemotherapy while giving pine pollen (150, 300, 600 mg/kg) by gavage, which can significantly improve the tumor inhibition rate of TP chemotherapy alone, and inhibit the weight loss and food intake reduction caused by chemotherapy drugs. , Inhibit the reduction of white blood cells and the damage of liver and kidney function caused by chemotherapy.

　　Conclusion: The administration of pine pollen at the same time of TP plan chemotherapy has obvious effect of increasing efficiency and reducing toxicity.