动物造模 z-bio 2021-09-27 353

　　Objective: To discuss the changes of rat's motor function with increasing age, and the effect of exercise on improving the motor function of elderly rats.

　　Method: Intervene with a two-week moderate-intensity treadmill exercise for 26-month-old, 8-month-old and 2-month-old SD rats, and measure the four functional indicators of forelimb tension, endurance, physical upward mobility and ultimate speed before and after exercise. , Stop comparing and analyzing.

　　Results: ①The 26-month-old rat group's forelimb tension, endurance, physical upward mobility, and ultimate speed were significantly lower than those of the 8-month-old group and the 2-month-old group, and the latter three indicators showed a decline with age; ②26-month-old and The forelimb pulling force of the 8-month-old group was higher after exercise than before the exercise, and the body of the 8-month-old group and the 2-month-old group could only move upwards after exercise. The 26-month-old group after exercise was significantly higher than before exercise.

　　Conclusion: The four motor function indexes of rat's forelimb tension, endurance, body upward mobility and limit speed show aging decline, which can be used as an aging indicator of rat's motor function. Moderate-intensity treadmill exercise can significantly improve the overall locomotor function of elderly rats.