动物造模,慢性缺血 z-bio 2021-09-27 226

　　Objective: To evaluate the effect of polyethylene oxide (PEO) on the blood perfusion of chronic ischemic hindlimbs in rats by contrast-enhanced ultrasound.

　　Method: Twelve Wistar rats were ligated one side of the femoral artery to establish a chronic hindlimb ischemia model, and then the rats were randomly divided into an experimental group and a control group (n=6). Saline, a total of 2 weeks of treatment. Acoustic contrast examination was performed at different time points to measure the blood flow of the skeletal muscles of the ischemic hindlimbs of the rats, and the blood flow storage was measured on the 28th day.

　　Results: From the 7th day, the blood flow of the ischemic hindlimb skeletal muscle of the rats in the PEO group was higher than that of the control group (P<0.05). On the 28th day, the blood flow storage and vascular volume of the ischemic hindlimb skeletal muscle of the PEO group were significantly higher than those in the control group. Control group (P<0.05).

　　Conclusion: PEO significantly improves the blood flow storage and blood flow of the skeletal muscle of the chronic hindlimb ischemia model rat, and increases the vascular volume of the skeletal muscle of the chronic ischemic hindlimb, suggesting that PEO may promote vascular regeneration and arteries by increasing the blood flow shear The formation process, thereby improving the blood perfusion of the ischemic hind limbs.