动物造模,产后压力性尿失禁大鼠模型 z-bio 2021-10-15 399

　　Objective: To study the effect of IGF-1 gene therapy on the rat model of postpartum stress urinary incontinence, and to explore the ideal treatment for the disease.

　　Method: Model 240 female SD rats with water sac vaginal dilation method, randomly select 148 from 185 victory models and divide them into 5 groups, respectively stop IGF-1 gene therapy, amino antagonist drug therapy, electrical stimulation therapy, Empty plasmid vector injection and untreated, another 20 unmodeled rats were selected as blank controls, and urodynamic testing and serum biochemical indicators (LDH, CK) testing were stopped in each group at 1, 21, 42 and 63 days after treatment. Wait, and observe the changes of pubococcygeus muscle fibers under a light microscope.

　　Results: At 21 days after treatment, the IGF-1 group and the electrical stimulation group had better therapeutic effects regardless of the maximum bladder volume, the pressure at the leak point, or the contraction force/muscle weight ratio; while the IGF-1 group and the electrical stimulation group had two better results. There was no significant difference in comparison between the groups (P>0.05).

　　Conclusion: IGF-1 gene therapy and electrical stimulation therapy are better than other groups such as drug therapy on the rat model of postpartum stress urinary incontinence.