动物造模,高脂血症 z-bio 2021-10-18 264

　　Objective: To discuss the effect of the combination of estrogen and androgen on the blood lipid level and coagulation function of hyperlipidemia mice.

　　Method: After castration of the mice, the hyperlipidemia model was established through a high-fat diet, and the mice were divided into 5 groups after giving different hormones. After the model was built, blood was collected from the mice. A part of the mouse serum was used to test the level of blood lipids in the mice, and the other part of the mouse plasma was used to test the coagulation function.

　　Results: After a high-fat diet, the levels of serum total cholesterol, triglycerides and low-density lipoprotein in mice were significantly higher than those in the control group, and the prothrombin time and the time to activate local prothrombin were significantly shortened (P<0.05) , After giving estrogen androgen combination therapy, compared with the model, the levels of total cholesterol, triglycerides and low-density lipoprotein in the mouse serum were significantly lower than those in the control group, prothrombin time and activated local prothrombin time Significantly prolonged (P<0.05), but no significant difference from the control group.

　　Conclusion: Estrogen combination therapy can regulate blood lipids, significantly reduce the level of low-density lipoprotein, and regulate blood coagulation. It suggests that the combination of estrogen and androgen can reduce the risk of coronary heart disease and provide new ideas for the hormone treatment of coronary heart disease.