动物造模 z-bio 2021-10-18 291

　　The development of the mammalian brain is a complex and orderly process that is highly accurately regulated. After a long period of research and discussion, scientists once had a certain understanding of brain development and established some fundamental laws.

　　Neuron migration is an indispensable and important link in brain development. Immature neurons follow a certain migration pattern to reach the correct location, and finally form a highly complex neural circuit. The classical theory in the past believed that excitatory main neurons stopped migrating radially along radial glial cells, while inhibitory interneurons mainly stopped migrating tangentially. These forms of migration have serious implications for brain functions and are the foundation of complex neural networks.

　　Hongjun Song and Guo-Li Ming from Johns Hopkins University recently put forward a challenge to the above-mentioned basic laws. Their research revealed that excitatory neuron precursors exhibit tangential migration in the brains of adult mammals. This surprising discovery was published in PNAS, the Proceedings of the National Academy of Sciences of the United States on July 13.

　　Song Hongjun and Ming Guoli are a couple of immortals. They fell in love as early as when they were studying at Peking University. Now they complement each other in their careers, and they have achieved one after another in the field of neuroscience. More than 60 research articles have been signed and published in international authoritative academic journals such as Cell, PNAS, Nat Neurosci, etc.

　　Researchers at Johns Hopkins University in the dentate gyrus of the mouse brain stopped in-depth analysis of excitatory neuron precursors and found significant tangential migration behavior. Further research has shown that this tangential migration mainly occurs in the neuroblast stage.

　　This research has further enriched people's understanding of mammalian neurodevelopment and laid an important conceptual foundation for the study of brain plasticity, brain diseases, and brain repair.