动物造模 z-bio 2021-10-25 252

　　Objective: To explore the differences in behavioral performance between SD and Wistar strains of rats in classical conditioning and operational conditioning, and to provide a basis for experimental animal selection for studying the advanced functions of the brain and establishing a stable animal model of conditioning.

　　Method: Select 8-week-old normal SD and Wistar rats to perform three detection modes: reward training, single operation training, and continuous multiple operation training to study the learning and memory ability of SD and Wistar rats.

　　Results: During the reward training, the number of nasal touches of SD rats increased significantly (vs.Wistar, P<0.05); during a single operation training, compared with SD rats, the total number of pedals (LPs) and ratio of Wistar rats (cLP/LP) significantly increased (P<0.05), the total number of nasal touches (NPs) was significantly different on the 5th day, the pedal latency was significantly reduced (P<0.05), and the pedal speed was significantly increased (P <0.05). In the continuous operation training, the number of nose touches in Wistar rats increased significantly (P<0.05), the="" number="" of="" pedals="" and="" rewards="" response="" accuracy="" rate="" was="" also="" higher="" than="" that="" sd="" but="" there="" no="" difference="" between="" groups.="" significance="" p="">0.05).

　　Conclusion: In the classical conditioning stage, SD rats have a strong ability to explore the drinking box and show a strong interest in reward substances; and Wistar rats perform better than SD rats in the reward operation conditioning phase.