动物造模 z-bio 2021-11-10 478

　　Objective: To lay the foundation for the research on the meridian gerbil population, and to provide data support for the researchers who use the meridian gerbil as the research object to develop animal models.

　　Methods: In this study, wild gerbils and experimental SD rats were used as the research objects. The morphological characteristics of the kidneys of the two were observed, and the parameters of kidney tissue morphology, kidney-to-body ratio, nephron density and other parameters were compared. .

　　Results: Comparison of the two kinds of rats: the ratio of renal medulla to cortical area, the ratio of inner medulla to cortical area, the ratio of inner medulla area to the area of kidney section, the ratio of the number of proximal and distal tubules per unit area The differences are statistically significant; the kidney-to-body ratio and nephron density of the two are also extremely significant interspecies differences.

　　Conclusion: The morphological and histological characteristics of the kidney indicate that the morphological structure of the kidney of wild gerbils has a greater correlation with its ability to concentrate urine, which is consistent with the kidney characteristics of drought-tolerant mammals.