2型糖尿病 z-bio 2021-11-25 699

　　Purpose: Observe the biological characteristics of db/db mice and provide a basis for the experimental research and application of this strain of animals.

　　Methods: Using spontaneous type 2 diabetes BKS.Cg-Dock7m+/+Leprdb/JNju mice and wild-type mice, the fasting blood glucose values were measured at 8, 12, 16, 20 and 24 weeks of age, 10, 12, 16, Body weight was measured at 20 and 24 weeks of age, and serum insulin, total cholesterol and triglyceride levels were measured at 24 weeks of age, organ quality and liver coefficient were measured, and histopathological observation was performed.

　　Results: The fasting blood glucose and body weight of db/db mice always maintained high levels; serum insulin, total cholesterol and triglyceride levels, as well as liver and kidney quality were significantly higher than wild-type mice; 24 weeks old Obvious pathological changes can be seen in the pancreas and liver tissues of db/db mice.

　　Conclusion: db/db mice have obvious characteristics of type 2 diabetes such as hyperglycemia, hyperlipidemia, and hyperinsulinemia, and are an ideal animal model for experimental research on type 2 diabetes.