动物造模 z-bio 2021-12-02 1074

　　By editing pig genes, pigs can produce human serum albumin, which can be used to treat blood loss and trauma, hemodialysis adjuvant therapy, etc.; patients with leukemia or tumors do not know which treatment method is more suitable for themselves, and can first use immunodeficiency mice Experiment.

　　Yesterday, the Chinese Academy of Sciences Guangzhou Institute of Biomedicine and Health Science and Technology Achievement Transformation Matchmaking Conference was held. At the conference, the reporter learned about a number of advanced scientific research projects in China and even in the world.

　　According to the Guangzhou Daily, the "Humanized Genetically Modified Pig Production Human Serum Albumin Project" carried out by Lai Liangxue's research group at the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences is precisely through the transformation of the pig serum albumin gene to completely produce human serum albumin. Serum albumin, thereby solving the problem of shortage of human serum albumin.

　　According to the introduction, the Guangzhou Institute of Biology has bred more than 30 genetically modified cloned pigs that fully express human serum albumin through this method.

　　It is understood that in 2015, my country's annual serum albumin consumption (including imports) reached 300 tons. Since the recombinant protein technology has not yet been officially marketed, the raw material plasma currently used is all limited sources.

　　The "clone pig" bred by Lai Liangxue's research group can collect blood twice a week, 1.5 liters or more each time, and produce more than 2.5 kg of serum albumin per year. It is expected to become an important source of serum albumin in the future.

　　Lai Liangxue pointed out that this technology is still in the research stage, and it needs to be applied to humans on a large scale, as well as solving biosafety issues. Like all animal-derived blood products and organ tissues, they must undergo strict safety monitoring and be approved by the State Food and Drug Administration before they can be officially put into use.