动物造模 z-bio 2021-12-06 557

　　Laboratory animals used in scientific research must exclude some microorganisms, including zoonotic pathogens, animal diseases, and some pathogens that seriously interfere with research. Animals that exclude some special pathogens are called SPF animals. There are some conditional pathogens that are not pathogenic to animals with normal immune function, so they are not listed as pathogens excluded by SPF in certain animal groups, such as Pseudomonas aeruginosa and Staphylococcus aureus. Conditional pathogens such as β-streptococcus, Klebsiella oxytoca, and Klebsiella pneumoniae are often found in the quality testing of experimental mice at home and abroad.

　　However, there are differences in the immune function of CC mice of different strains. Some conditional pathogenic bacteria on immune-sound mice may be serious pathogenic microorganisms in some CC strains. For example, Pseudomonas aeruginosa is widely distributed in nature and is mainly spread through contact and air. It is a pathogenic microorganism that is not easy to exclude. The survival time and survival rate of different strains of CC mice after infection with Pseudomonas aeruginosa are different. Among them, IL256, IL521, IL2689, IL3438 strains have the longest average survival time after infection; IL711, IL1061, IL188, IL2126, IL1912 Strain mice have the shortest average survival time after infection. Therefore, for CC mice, the scope of SPF exclusion of pathogens may require more consideration.