动物造模,主动脉炎症 z-bio 2021-12-31 1064

　　Objective To observe the effects of Naoshuantong Capsules on the inflammation-related factors interleukin-1β (interleukin-1 beta, IL-1β), interleukin-6 (interleukin-6, IL-6) and tumors in ApoE-/- atherosclerosis mouse model. Necrosis factor (tumor necrosis factor-α, TNF-α), intercellular cell adhesion molecule-1 (ICAM-1) and metalloproteinase-9 (matrix metalloproteinase, MMP-9) expression, Preliminarily explore the mechanism of its treatment of atherosclerosis.

　　Methods 8-week-old male ApoE-/- mice were used high-fat diet to establish atherosclerosis model. After successful modeling, they were randomly divided into model control group, Naoshuantong capsule low-dose group, and Naoshuantong capsule high-dose group . The low-dose group was given Naoshuantong capsule 0.5 g/kg body weight, the high-dose group was given Naoshuantong capsule 1.0 g/kg body weight, and the model control group was given the same amount of distilled water. After continuous administration for 12 weeks, the whole aortic intimal plaque was detected by red oil O staining, and the inflammation-related factors IL-1β, IL-6, TNF-α, ICAM-1 and MMP-9 of each group of mice were observed and compared. Express.

　　Results After drug intervention, the aortic plaque area of the Naoshuantong Capsule high-dose group was significantly lower than that of the model control group (P<0.01). Compared with the model control group, the Naoshuantong capsule low-dose group can inhibit the protein expression levels of inflammation-related factors IL-1β and IL-6, respectively (P<0.05), and the high-dose Naoshuantong group IL-1β The expressions of, IL-6, TNF-α and ICAM-1 were all reduced (P<0. 05, P<0. mmp-9="" p="">0. 05).

　　Conclusion Naoshuantong Capsules can regulate the expression levels of inflammation-related factors, and its mechanism of treating atherosclerosis may be related to this pathway.