动物造模,抑郁症 z-bio 2022-01-06 780

　　Objective To investigate the effects of Viprofamine capsules combined with Fluoxetine Hydrochloride Capsules on depression in mice.

　　Method A mouse depression model was established by the method of chronic stress and orphanism. Randomly divided into 5 groups: blank control group, model group, viprozine hydrochloride group, fluoxetine hydrochloride group and viprozine combined with fluoxetine hydrochloride group (combined medication group), 10 rats in each group, and continuous intragastric administration for 30 days. The body weight changes, sugar water preference rate, forced swimming immobility time and tail suspension time of each group of mice were observed for comparison and analysis, and the effect of combined medication on depression mice was comprehensively evaluated.

　　Results When the modeling was completed (day 0), compared with the blank control, the total sugar water consumption, sugar water preference rate and body weight of each depression model group were significantly reduced (P<0.01). After intragastric administration, the body mass of the animals in the experimental groups increased. On the 30th day, compared with the model group, there was a significant difference in the body mass increase of the combined drug group (P<0.05). On the 39th day, the vinprofen group There was a significant difference in weight gain (P<0.05). On the 46th day, there was a significant difference in body weight gain between the combined administration group and the fluoxetine hydrochloride group (P<0.05). On the 50th day, the total sugar water consumption and sugar water preference rate of each treatment group increased to different degrees. Compared with the model group, there were significant differences in the total sugar water consumption and sugar water preference rate of the vinpropylamine group (P<0.05) , Compared with the model group, the total consumption of sugar and water in the combination group has a significant difference (P<0.05), and the preference rate of sugar and water in the combination group has a very significant difference (P<0.01). The time of forced swimming immobility and tail suspension time were significantly reduced in the Viprozine group and the combination medication group. Compared with the model group, there were significant differences in swimming and tail suspension time in the Viprozine group (P<0.05). The combination medication group The immobility time of the tail suspension was significantly different (P<0.01). Compared with the fluoxetine hydrochloride group, the immobility time of the tail suspension of the combined medication group was significantly different (P<0.05).

　　Conclusion Experiments have shown that vilpromide has an antidepressant effect, and the combined effect of fluoxetine hydrochloride is better. This study will provide experimental evidence and references for clinical medications for clinical depression.