动物造模 z-bio 2022-01-19 398

　　Objective: To evaluate the effect of continuous high-frequency sine-wave and square-wave stroboscopic flashes on emmetropia and eye development in guinea pigs.

　　Methods: Thirty 2-week-old guinea pigs were divided into 3 groups (n=10), 20 Hz square wave, 20 Hz sine wave stroboscopic group and no stroboscopic control group. The diopter, axial length and radius of curvature were measured. The three groups of guinea pigs were examined by electrophysiological flash electroretinography (F-ERG) at the 8th week.

　　Results: There was a positive correlation between the eyeball diopter and the axial length of the guinea pigs in the three groups. Compared with the control group at the 8th week, the 20 Hz sine wave stroboscopic group and the 20 Hz square wave diopter appeared (-0.75±0.79) D and (-1.50±1.50± 0.91) D myopic changes (P < 0.05), no significant difference in radius of curvature among the three groups (P > 0.05), F-ERG latency 20 Hz sine wave and 20 Hz square wave stroboscopic group a wave prolonged 3.8 s and 7.9 s s, There was no significant difference in histology among the three groups.

　　Conclusion: Continuous exposure to high-frequency square-wave and sine-wave stroboscopic flashes affects emmetropia to some extent.