动物模型 z-bo 2020-08-11 505

　　The model was established by Marmarou in 1994. The specific steps of making the model are: laying the rat prone on the foam pad, cutting the skin longitudinally, exposing the skull vault. Fix an iron disc (10mm in diameter and 3mm in thickness) on the top surface of the skull at the coronal seam and the herringbone seam. Its base is curved and fits the top of the skull. A 450mg hammer is sleeved in plexiglass with an inner diameter of 19mm and a length of 2m. The tube fell and hit the iron plate, causing head stress and head injury. Because the existence of the foam pad ensures the instantaneity of the external force, and the iron disc ensures the diffuseness of the external force, a diffuse brain injury model can be prepared.

　　The model method is simple, the conditions are easy to control, the skull drilling reduces the error caused by the individual variation of the skull, and the repeatability is good. Controlling the weight of heavy objects and the height of falling can control the severity of the injury. It is now commonly used by most researchers at home and abroad to study the molecular mechanism of brain injury.