动物实验 z-bio 2022-02-09 253

　　Objective: To discuss the effects of different animal experimental anesthetics on the cardiovascular system of rats.

　　Methods: BioPac MP150 was used to dynamically record the electrocardiogram and blood pressure of rats after anesthesia with four kinds of anesthesia drugs.

　　Results: Chloral hydrate can cause severe ventricular arrhythmia, isoflurane has inhibitory effect on heart rate, pentobarbital sodium can cause the increase of the P wave of the rat's electrocardiogram, and urethane can cause the increase of the J point of the rat's electrocardiogram. Both urethane and pentobarbital sodium can increase SBP, chloral hydrate can increase CK, isoflurane can reduce CK and CKMB, pentobarbital sodium and isoflurane can reduce ALT and AST. Chloral hydrate, sodium pentobarbital and isoflurane can reduce creatinine, and the four anesthetics can reduce blood sodium and potassium.

　　Conclusion: Chloral hydrate has obvious effects on the cardiovascular system, and it is not suitable for animal experimental research on cardiovascular disease. Sodium pentobarbital, urethane, and isoflurane can be selected as animal experimental research on cardiovascular disease.